Systematic investigations were carried out on biopolymer solutions (alginate and chitosan) to gain a deeper understanding of the freeze-structuring process. In this thesis, scaffolds with a highly ordered and anisotropic pore structure were fabricated using unidirectional freezing. Anisotropic porosity would have the advantage of facilitating the ingrowth of cells and newly formed blood vessels as well as the transport of nutrients. In the field of bone replacement, the pore structure of the material has a crucial influence. In many cases, the loss of these tissues requires reconstruction using biocompatible replacement materials. The benefit of this, of course, would beĪ multitude of human tissues, such as bones, tendons, or muscles, are characterized by a hierarchical and highly ordered structure. Out, should initiate much wider scientific interest, which would, in turn, lead to reconciliation of some exceeded conceptsĪbout developmental, electrical, mechanical and energetical events in human heart. Recent validations of the ventricular myocardial band, reviewed here, as well as future research directions that are pointed On macroscopic structure of the ventricular myocardium, this concept has provided a promising ground for its final understanding. After more than five centuries long debate The ventricular myocardial band concept, developed over the last 50 years, has revealed unavoidableĬoherence and mutual coupling of form and function in the ventricular myocardium. Or not, many questions in cardiovascular medicine are still pending, due to our insufficient insight in the basic science.Įven so, any new concept encounters difficulties, mainly arising from our inert attitude, which may result either in unjustifiedĪcceptance or denial. Structure and function in any organ are inseparable categories, both in health and disease.
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